Effective Therapy.
Proven Results.

Models used for illustrative purposes only.  
 

Indications

BETASERON® (interferon beta-1b) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.



BETASERON® (interferon beta-1b) can help

In patients with clinically isolated syndrome (CIS), BETASERON® (interferon beta-1b) was PROVEN to

In patients living with relapsing-remitting multiple sclerosis (RRMS), BETASERON was PROVEN to

PROVEN to significantly delay time to a second flare-up in patients with CIS

In a 2-year study, 292 patients with clinically isolated syndrome* who started treatment early with BETASERON significantly reduced their likelihood of having a second flare-up compared with 176 patients on placebo

BETASERON cut risk of a second flare-up in half
50%
less risk
Likelihood of a second flare-up within 2 years:
BETASERON® (interferon beta-1b) Efficacy
28%
with BETASERON
45%
with placebo
*Patients included in the BENEFIT Study experienced a first neurological event suggestive of multiple sclerosis, which is also referred to as clinically isolated
  syndrome. Patients also had at least 2 lesions on a T2-weighted brain MRI scan that did not cause any symptoms.

By proportional hazard ratio regression adjusted for age/gender/steroids/T2 lesions/Gd lesions.

PROVEN to reduce the number of newly active brain lesions in patients with CIS

MRI data from a 2-year study showed that BETASERON patients with the first symptoms of MS had fewer newly active lesions at 2 years

BETASERON reduced the number of brain lesions
56%
fewer newly active lesions
Newly active brain lesions:
BETASERON® (interferon beta-1b) Efficacy
3.7
with BETASERON
(292 people)
8.5
with placebo
(176 people)
Newly active lesions=nonenhancing new or enlarging T2 lesions; new Gd-enhancing lesions. (P<0.0001, hazard ratio: 0.50). The exact relationship between MRI findings and the clinical status of patients is not known.

Important Safety Information (cont'd)

BETASERON can cause serious side effects, including:

Liver Problems Including Liver Failure. Symptoms of liver problems may include yellowing of your eyes, itchy skin, feeling very tired, flu-like symptoms, nausea or vomiting, bruising easily or bleeding problems. Your healthcare provider will do blood tests to check for these problems while you take BETASERON.

Please see additional Important Safety Information below.

PROVEN to cut frequency of flare-ups in patients with RRMS

In a 2-year study, 124 patients taking BETASERON had 31% fewer relapses than 123 patients taking placebo

The second main result showed the proportion of patients who had not had a flare-up at 2 years did not significantly differ between the placebo (16%) and BETASERON (25%) treatment groups

BETASERON cut the frequency of
flare-ups
31%
fewer
flare-ups§
Flare-ups per year:
BETASERON® (interferon beta-1b) Efficacy
0.9
with BETASERON
1.31
with placebo
§All patients were ambulatory with EDSS scores of 5.5 or less and had at least 2 acute exacerbations during the previous 2 years.

Important Safety Information (cont'd)

BETASERON can cause serious side effects, including:

Serious Allergic Reactions. Serious allergic reactions can happen quickly and may happen after your first dose of BETASERON or after you have taken BETASERON many times. Symptoms may include difficulty breathing or swallowing, swelling of the mouth or tongue, rash, itching, or skin bumps.

Understand Safety

It's important to know the possible risks and benefits of BETASERON. Make sure you talk to your doctor to understand which possible side effects are more serious than others, as well as those that are more common.
Start a discussion, BETASERON® (interferon beta-1b)

Be prepared for your next doctor visit

Download our brochure on clinically isolated syndrome and use the doctor discussion guide.
BETAPLUS is there 24/7, BETASERON® (interferon beta-1b)

Questions about BETASERON? Call 1-844-788-1470

Questions about BETASERON? Call 1-844-788-1470

An MS-trained BETA Nurse is available anytime, day or night.

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