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Healthcare Professionals  questions in your Checklist
Important Safety Information

Do not take BETASERON® (interferon beta-1b) if you are allergic to interferon beta-1b, to another interferon beta, to human albumin, or mannitol. See additional Important Safety Information below.

Important Safety Information
Prescribing Information and Medication Guide
Do not take BETASERON® (interferon beta-1b) if you are allergic to interferon beta-1b, to another interferon beta, to human albumin, or mannitol.
See additional Important Safety Information below.

I've got questions

A BETA Nurse is available 24/7/365.

While your healthcare provider is the best one to answer questions about relapsing-remitting multiple sclerosis (RRMS) and treatment options, your BETA Nurse is also a dependable resource.

Here are some commonly asked questions about RRMS and BETASERON® (interferon beta-1b).

Why should I start a therapy if I'm not experiencing any noticeable symptoms?

The fact is, RRMS can be deceiving. Whether you're experiencing relapses or not, RRMS can be an active disease1. Remember, being free of symptoms doesn't mean you're free of RRMS.

How do I choose a therapy that is right for me?

Everyone is different, and there are many factors to consider when choosing a treatment. And some aspects of therapy may be intimidating, like the thought of having to inject yourself. But staying focused now is important. Making the right treatment choice will help make taking your therapy easier for you, which may help you achieve better results.

Here are some things you might want to discuss with your healthcare provider when choosing a therapy:

  • Does it help reduce the frequency of relapses?
  • What are the side effects and are there tips to help reduce any of them?
  • If the therapy is injectable, does it have to be refrigerated?
  • Is there a program to help me if I have health insurance problems?
  • Can I get financial assistance?
  • Is there 24/7 support?

What BETASERON benefits should I know about?

Bayer conducted a 2-year study evaluating the safety and efficacy of BETASERON in CIS patients. This study found that when used at the first signs of MS, BETASERON helped significantly delay the time to a second flare-up (conversion to clinically definite MS) compared with placebo.

Other BETASERON benefits to consider:

  • Every-other-day dosing4
  • One of the thinnest needles available in MS therapy
  • Refrigeration-free storage for easy traveling*4
  • The BETAPLUS® Patient Support program offers copay assistance, and nurse access and training

*BETASERON can be stored at room temperature until its expiration date and before reconstitution. If not used immediately after reconstitution, the product should be refrigerated and used within 3 hours. Do not freeze BETASERON.

What important information should I know about BETASERON?

INDICATIONS

BETASERON® (interferon beta-1b) is a prescription medicine used to reduce the number of relapses in people with relapsing forms of multiple sclerosis (MS). This includes people who have had their first symptoms of multiple sclerosis and have an MRI consistent with multiple sclerosis. BETASERON will not cure MS but may decrease the number of flare-ups of the disease.


IMPORTANT SAFETY INFORMATION

Do not take BETASERON (interferon beta-1b) if you are allergic to interferon beta-1b, to another interferon beta, to human albumin, or mannitol.

BETASERON can cause serious side effects, including:

Liver Problems Including Liver Failure. Symptoms of liver problems may include yellowing of your eyes, itchy skin, feeling very tired, flu-like symptoms, nausea or vomiting, bruising easily or bleeding problems. Your healthcare provider will do blood tests to check for these problems while you take BETASERON.

Serious Allergic Reactions. Serious allergic reactions can happen quickly and may happen after your first dose of BETASERON or after you have taken BETASERON many times. Symptoms may include difficulty breathing or swallowing, swelling of the mouth or tongue, rash, itching, or skin bumps.

Depression or Suicidal Thoughts. Call your healthcare provider right away if you have any of the following symptoms, especially if they are new, worse or worry you: thoughts about suicide or dying, new or worse depression (sinking feeling or sadness), new or worse anxiety (feeling uneasy, nervous or fearful for no reason), trouble sleeping (insomnia), acting aggressive, being angry, or violent, acting on dangerous impulses, hallucinations, other unusual changes in behavior or mood.

Other possible serious side effects with BETASERON include:

Heart Problems. BETASERON may worsen heart problems including congestive heart failure. Symptoms of heart problems may include swollen ankles, shortness of breath, decreased ability to exercise, fast heartbeat, tightness in chest, increased need to urinate at night, not being able to lay flat in bed.

Injection Site Problems. Serious skin reactions can happen in some people including areas of severe damage to skin and the tissue below the skin (necrosis). These reactions can happen anywhere you inject BETASERON. Symptoms of injection site problems may include swelling, redness, or pain at the injection site, fluid drainage from the injection site, breaks in your skin or blue-black skin discoloration. Change your injection site each time you inject BETASERON as it will lessen the chance of you having a serious skin reaction. Avoid injecting BETASERON into an area of the skin that is sore, reddened, infected or has other problems.

Flu-like Symptoms. BETASERON can cause flu-like symptoms including fever, chills, tiredness, sweating, muscle aches when you first start to use it. These symptoms may decrease over time. Taking medicines for fever and pain relief on the days you are using BETASERON may help decrease these symptoms.

Seizures. Some people have had seizures while taking BETASERON, including people who have never had seizures before. It is not known if the seizures were related to MS, to BETASERON, or to a combination of both. If you have a seizure after taking BETASERON call your healthcare provider right away.

Blood Problems. You may have a drop in the levels of infection-fighting white blood cells, red blood cells, or cells that help you form blood clots. If drops in levels are severe, they can lessen your ability to fight infections, make you feel tired or sluggish or cause you to bruise or bleed easily.

Risk to Pregnancy:
BETASERON can harm your unborn baby. BETASERON may cause you to lose your baby (miscarry). If you become pregnant while taking BETASERON call your healthcare provider right away. You and your healthcare provider should decide if you should continue to take BETASERON.

Most Common Side Effects:
The most common side effects of BETASERON include low white blood cell count, increases in your liver enzymes, headache, increase in your muscle tension, pain, rash, problems sleeping, stomach pain, weakness. These are not all the possible side effects of BETASERON.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. Tell your healthcare provider about all the medicines you take and your medical conditions.

Please see the full Prescribing Information and Medication Guide for additional information and talk to your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

How do I get personal injection training?

Every person taking BETASERON can get personal injection training from an MS-trained BETA Nurse. Your BETA Nurse can make sure you're confident using and injecting BETASERON. It's like having your own BETASERON expert on call. To schedule a time for a BETA Nurse to come to your home* or healthcare provider's office, call BETAPLUS at 1-800-788-1467.

*Where state law and your insurance allow.

Are there tips to help reduce injection-site reactions?

One thing you can do to help reduce injection-site reactions (ISRs) is to rotate your injection sites. Never use the same injection site twice in a row. If an area is sore, red, infected, or swollen, use another area and call your healthcare provider.

The important thing is to make taking your BETASERON a part of your routine. Taking it at the same time every other day can help you remember.

What are some tips to help with flu-like symptoms?

  • Take an over-the-counter pain reliever
    Before injecting BETASERON, take an over-the-counter pain reliever as recommended by your doctor.
  • Titrate (gradually increasing your dose)
    Your doctor may start you on a lower dose and then increase the dose gradually as your body adjusts to the therapy.

How do I store BETASERON?

BETASERON can be stored refrigeration-free*. That means no traveling with a cooler or having to keep it cold in a hotel room. And because BETASERON can be stored at room temperature (77°F, 25°C), there's no waiting for it to warm up before injecting.

*BETASERON can be stored at room temperature until its expiration date and before reconstitution. If not used immediately after reconstitution, the product should be refrigerated and used within 3 hours. Do not freeze BETASERON.

Indications

BETASERON® (interferon beta-1b) is a prescription medicine used to reduce the number of relapses in people with relapsing forms of multiple sclerosis (MS). This includes people who have had their first symptoms of multiple sclerosis and have an MRI consistent with multiple sclerosis. BETASERON will not cure MS but may decrease the number of flare-ups of the disease.


Important Safety Information

Do not take BETASERON (interferon beta-1b) if you are allergic to interferon beta-1b, to another interferon beta, to human albumin, or mannitol.

BETASERON can cause serious side effects, including:

Liver Problems Including Liver Failure. Symptoms of liver problems may include yellowing of your eyes, itchy skin, feeling very tired, flu-like symptoms, nausea or vomiting, bruising easily or bleeding problems. Your healthcare provider will do blood tests to check for these problems while you take BETASERON.

Serious Allergic Reactions. Serious allergic reactions can happen quickly and may happen after your first dose of BETASERON or after you have taken BETASERON many times. Symptoms may include difficulty breathing or swallowing, swelling of the mouth or tongue, rash, itching, or skin bumps.

Depression or Suicidal Thoughts. Call your healthcare provider right away if you have any of the following symptoms, especially if they are new, worse or worry you: thoughts about suicide or dying, new or worse depression (sinking feeling or sadness), new or worse anxiety (feeling uneasy, nervous or fearful for no reason), trouble sleeping (insomnia), acting aggressive, being angry, or violent, acting on dangerous impulses, hallucinations, other unusual changes in behavior or mood.

Other possible serious side effects with BETASERON include:

Heart Problems. BETASERON may worsen heart problems including congestive heart failure. Symptoms of heart problems may include swollen ankles, shortness of breath, decreased ability to exercise, fast heartbeat, tightness in chest, increased need to urinate at night, not being able to lay flat in bed.

Injection Site Problems. Serious skin reactions can happen in some people including areas of severe damage to skin and the tissue below the skin (necrosis). These reactions can happen anywhere you inject BETASERON. Symptoms of injection site problems may include swelling, redness, or pain at the injection site, fluid drainage from the injection site, breaks in your skin or blue-black skin discoloration. Change your injection site each time you inject BETASERON as it will lessen the chance of you having a serious skin reaction. Avoid injecting BETASERON into an area of the skin that is sore, reddened, infected or has other problems.

Flu-like Symptoms. BETASERON can cause flu-like symptoms including fever, chills, tiredness, sweating, muscle aches when you first start to use it. These symptoms may decrease over time. Taking medicines for fever and pain relief on the days you are using BETASERON may help decrease these symptoms.

Seizures. Some people have had seizures while taking BETASERON, including people who have never had seizures before. It is not known if the seizures were related to MS, to BETASERON, or to a combination of both. If you have a seizure after taking BETASERON call your healthcare provider right away.

Blood Problems. You may have a drop in the levels of infection-fighting white blood cells, red blood cells, or cells that help you form blood clots. If drops in levels are severe, they can lessen your ability to fight infections, make you feel tired or sluggish or cause you to bruise or bleed easily.

Risk to Pregnancy:
BETASERON can harm your unborn baby. BETASERON may cause you to lose your baby (miscarry). If you become pregnant while taking BETASERON call your healthcare provider right away. You and your healthcare provider should decide if you should continue to take BETASERON.

Most Common Side Effects:
The most common side effects of BETASERON include low white blood cell count, increases in your liver enzymes, headache, increase in your muscle tension, pain, rash, problems sleeping, stomach pain, weakness. These are not all the possible side effects of BETASERON.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. Tell your healthcare provider about all the medicines you take and your medical conditions.

Please see the full Prescribing Information and Medication Guide for additional information and talk to your healthcare provider.