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IMPORTANT SAFETY INFORMATIONSafety InformationMedication Guide

The most commonly reported adverse reactions are lymphopenia, injection-site reaction, asthenia, flu-like symptom complex, headache, and pain. Gradual dose titration and use of analgesics during treatment initiation may help reduce flu-like symptoms... continue reading below

Travel Card

Taking a Trip? Bring Your BETAPLUS® Travel Card

Taking a trip can be fun, but it can also take some planning if you take medication. When traveling with BETASERON (interferon beta-1b), be sure to show your BETAPLUS Travel Card if you're asked about your medication and syringes.

Here are some things to do when you're traveling with your BETASERON to help make your trip go smoothly:

  • Show your BETAPLUS Travel Card if you're asked about your medication and syringes
  • Take a current prescription label (located on the outside of the packaging) with you
  • Carry a physician's note on his or her stationery indicating that you are living with multiple sclerosis (MS) and require injections
  • Write the telephone number of your physician's office on your BETAPLUS Travel Card in case you run out of medication while traveling
  • Carry a durable container to put used needles and syringes in
  • Take your Personal Journal to record your medication use while you're away

BETASERON Storage Conditions

BETASERON can be stored refrigeration-free for greater than 30 days,* which helps make traveling with BETASERON convenient.

BETASERON can go practically anywhere, since it can be stored at room temperature (77°F) with an excursion range of 59°F to 86°F. You should keep BETASERON out of areas exposed to the sun, such as the dashboard of a car.

Tips for Flying

Keep in mind that different airline carriers have different policies regarding carry-on bags and luggage. When traveling with syringes:

  • Call in advance to find out about specific regulations
  • Check the laws of your destination country
  • Call the US Department of Transportation at 1-800-778-4838 to hear about your rights under the federal Air Carrier Access Act

Effect of X-rays

Normal exposure to X-ray at a security checkpoint has been shown to have no effect on the stability of BETASERON.

* BETASERON can be stored at room temperature for longer than 30 days. After reconstitution, if not used immediately, the product should be refrigerated and used within 3 hours.

†Based on a study in which sample vials of medication were subjected to 2 X-ray exposures prior to reconstitution.

INDICATIONS AND USAGE

BETASERON® (interferon beta-1b) is indicated for the treatment of relapsing forms of multiple sclerosis to reduce the frequency of clinical exacerbations. Patients with multiple sclerosis in whom efficacy has been demonstrated include patients who have experienced a first clinical episode and have MRI features consistent with multiple sclerosis.

IMPORTANT SAFETY INFORMATION

The most commonly reported adverse reactions are lymphopenia, injection-site reaction, asthenia, flu-like symptom complex, headache, and pain. Gradual dose titration and use of analgesics during treatment initiation may help reduce flu-like symptoms. BETASERON should be used with caution in patients with depression. Injection-site necrosis has been reported in 4% of patients in controlled trials. Patients should be advised of the importance of rotating injection sites. Female patients should be warned about the potential risk to pregnancy. Cases of anaphylaxis have been reported rarely. See "Warnings," "Precautions," and "Adverse Reactions" sections of full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

For important risk and use information, please see the full prescribing information.

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** In a survey of 199 physicians conducted by JZM/Phoenix Healthcare Practice, BETAPLUS, an MS patient support program for those on Betaseron, was rated "best" for affordable therapy, copay assistance, and nurse access and training, compared to MS support programs from Avonex, Copaxone, and Rebif. Attitude, Awareness and Use Tracking Study Among Physicians June 2008.

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